NLRP3 inflammasome in sepsis (Review)

Sepsis is an imbalanced response to infection that leads life-threatening organ dysfunction. Although increasing number of anti-inflammatory drugs are available, the options for treating sepsis remain limited. Therefore, it imperative understand pathogenesis and pathophysiology develop novel therapeutic targets treat this state. The Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome a cytoplasmic high-molecular weight protein complex composed sensor NLRP3, adapter apoptosis-related speck-like pro-caspase-1. It functions by cleaving pro-caspase-1 become active caspase-1, resulting in maturation release IL-1β IL-18. Activation NLRP3 necessary innate immune defense also serves important role adaptive responses. Studies have shown involved occurrence evolution other inflammatory diseases. present paper reviews activation pathways biological function sepsis, with aim provide basis further research.